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Eurachem - a focus for analytical chemistry in Europe

Measurement Uncertainty

Background

Measurement uncertainty is an important topic for all measurement fields, and analytical measurement is no exception. No measurement result can be interpreted correctly without at least some knowledge of the associated uncertainty; either the user needs to know how large the uncertainty is so that they can make appropriate allowances, or they need assurance that the associated uncertainty is sufficiently small to neglect for their particular purpose. Establishing sufficient knowledge and control of measurement uncertainty and communicating that knowledge to the client when required are therefore among the responsibilities of every laboratory.

Laboratories accredited to ISO/IEC 17025 or related standards such as ISO 15189 will be familiar with this responsibility, as these standards require laboratories to identify the main contributions to uncertainty and to provide estimates of uncertainty where appropriate. For calibration laboratories and reference material producers, the requirements are more stringent; uncertainties need to be evaluated following current international guidelines and reported on calibration certificates.

Resources

Eurachem provides a range of resources to assist laboratories responsible for evaluating, using or reporting measurement uncertainty associated with analytical measurement results:

  • The Eurachem Measurement Uncertainty and Traceability working group develops guidance and coordinates workshops on measurement uncertainty for analytical measurement.
  • The Eurachem guide "Quantifying uncertainty in analytical measurement (QUAM:2012)", currently in its second edition, gives detailed guidance for the evaluation and expression of uncertainty in quantitative chemical analysis, based on the approach taken in the ISO “Guide to the Expression of Uncertainty in Measurement”. The guide provides a range of approaches to uncertainty evaluation, including the use of method validation data as well as the detailed measurement model approach described in the ISO Guide. QUAM:2000 also gives details of essential statistical procedures (for example, the assessment of uncertainty from linear calibration), provides practical guidance such as cause-and effect analysis for identifying sources of uncerainty and a detailed description of uncertainty evaluation using spreadsheets, and includes detailed worked examples illustrating many common operations in uncertainty evaluation for chemical measurement.
  • A further guide, "Use of uncertainty information in compliance assessment", gives additional detail on the use of uncertainty information when assessing compliance with specifications, including legal limits.
  • The Eurachem working group on uncertainty arising from sampling has published a first edition of the guide "Measurement uncertainty arising from sampling: A guide to methods and approaches".  This guide describes different methods for assessing uncertainties related to sampling, including a simple and general method based on replicated sampling.
  • Two information leaflets provide summary information on measurement uncertainty. The "Information leaflet for lab customers concerning the quality of chemical analyses", developed by SP, provides a simple explanation of measurement uncertainty for laboratory customers.  In addition, the principles of the compliance assessment guide above are summarised in the leaflet "Use of uncertainty information in compliance assessment".